Helminth therapies: translating the unknown unknowns to known knowns.

Known knowns, known unknowns, unknown unknowns and unknown knowns in DNA barcoding: a comment on Dowton et al.

RUPERT A. COLLINS1∗ AND ROBERT H. CRUICKSHANK2 1Laboratório de Evolução e Genética Animal, Departamento de Biologia, Universidade Federal do Amazonas, Av. Rodrigo Otávio, Manaus, Amazonas, Brazil and 2Department of Ecology, Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, Canterbury, New Zealand ∗Correspondence to be sent to: Departamento de Biologia, Universidade Fed...

Known knowns, known unknowns, and unknown unknowns: can systems medicine provide a new approach to sepsis?

Unknown knowns: Tacit knowledge in requirements engineering

Donald Rumsfeld famously identified three classes of knowledge: known knowns, known unknowns and unknown unknowns. The three knowledge classes map surprisingly well onto requirements knowledge but are all outside the scope of this panel. Our focus is on what Rumsfeld missed: unknown knowns. In RE terms, an unknown known is knowledge that a person (say, a customer) holds, but which they withhold...

S Peaking between the K Nown and the U Nknown

One of the things for which Donald Rumsfeld will be remembered is his distinction between ‘known knowns’, ‘known unknowns’ and ‘unknown unknowns’. He was speaking in 2002, at a press conference where he was commenting on the absence of evidence linking the government of Iraq with the supply of weapons of mass destruction to terrorist groups: There are known knowns; there are things we know that...

“Known Knowns, Known Unknowns, & Unknown Unknowns”: Computational Science challenges for analysis of multi-dimensional DNA matrices in Evolutionary & Population Genomics

The advent of so-called NextGen DNA sequencing methods has massively increased the rate at which DNA sequence information can be generated, and the volume and complexity of the data matrices that apply to biological questions, including molecular and organismal evolution and population biology. One such approach is the analysis of complete mitochondrial DNA (mtDNA) genomes from multiple species...